Tirzepatide is a weekly dual GIP and GLP-1 receptor agonist made by Eli Lilly.
Medi-Cal, Mounjaro and Zepbound
The Medi-Cal change applies to weight loss. KFF Health News reports that GLP-1 uses other than weight loss can still be covered when medically necessary, and members under 21 keep coverage [2]. Mounjaro is approved for type 2 diabetes [6]; Zepbound is approved for weight management and for moderate to severe sleep apnea in adults with obesity [7]. About 10.0% of San Diego County adults report diagnosed diabetes [3].
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Zepbound self-pay, dose by dose
| Dose | Price | Source |
|---|---|---|
| 2.5 mg | $299 | [1] |
| 5 mg | $399 | [1] |
| 7.5 to 15 mg, refilled within 45 days | $449 | [1] |
| Mounjaro, list price per 28 days | $1,112.16 | [9] |
Sleep apnea: a second reason to ask about Zepbound
FDA approved Zepbound for moderate to severe obstructive sleep apnea in adults with obesity on Dec 20 2024 [10]. In the label's sleep apnea trials, breathing events per hour fell by 25.3 and 29.3 on average versus about 5 on placebo at 52 weeks [11]. Coverage for the sleep apnea use can differ from coverage for weight loss, so ask your plan about it; see Zepbound insurance.
Getting it safely
- Prescribers: primary care, endocrinology, sleep medicine, or online programs. Ask any local health system whether it prescribes tirzepatide and how it bills.
- Check the license with the Medical Board of California [5].
- Compounded tirzepatide is not FDA-approved; FDA counts more than 730 adverse event reports for it as of May 31 2026 [12]. See compounded tirzepatide.
- Results: SURMOUNT-1 participants on 15 mg lost 20.9% of body weight on average at 72 weeks [13].
Label warnings
Thyroid C-cell tumor boxed warning; not for people with medullary thyroid carcinoma or MEN 2 in the family. Severe stomach pain that does not go away can mean pancreatitis. Tell your anesthesia team you take it before any procedure, because aspiration has been reported [11]. Call 911 for emergencies.
Other cities: Los Angeles, Las Vegas, Sacramento. Overview: tirzepatide, tirzepatide near me.
Questions people ask
How much is Zepbound in San Diego?
LillyDirect self-pay is $299 for 2.5 mg, $399 for 5 mg and $449 for 7.5 to 15 mg when refilled within 45 days, as of Oct 17 2026 [1].
Does Medi-Cal cover Mounjaro for diabetes?
Medi-Cal ended GLP-1 coverage only for adult weight loss on Jan 1 2026; uses other than weight loss can be covered if medically necessary [2]. Check your plan's formulary.
Is Zepbound approved for sleep apnea?
Yes. Zepbound is approved for moderate to severe obstructive sleep apnea in adults with obesity [7].
How do I check a tirzepatide prescriber in California?
Enter the prescriber's name in the Medical Board of California license search [5].
How many adverse events has FDA logged for compounded tirzepatide?
More than 730 reports as of May 31 2026, which FDA says is likely an undercount [12].
What diabetes rate does San Diego County have?
CDC PLACES estimates 10.0% of San Diego County adults had diagnosed diabetes in 2023 [3].
Sources
13 cited
- Zepbound self-pay pricing. Eli Lilly and Company (LillyDirect), Oct 17, 2026.
- California Medicaid ends coverage of GLP-1 weight loss drugs. KFF Health News, Jan 9, 2026.
- PLACES: County Data, San Diego County (2025 release, BRFSS 2023). CDC, 2023.
- QuickFacts: San Diego city, California. U.S. Census Bureau, 2025.
- Medical Board of California. State of California, Oct 17, 2026.
- Mounjaro label. DailyMed, National Library of Medicine, Aug 2026.
- Zepbound label. DailyMed, National Library of Medicine, Aug 2026.
- Lilly lowers Zepbound vial prices (press release). Eli Lilly and Company, Dec 1, 2025.
- Mounjaro FAQ. Eli Lilly and Company, Oct 17, 2026.
- FDA approves first medication for obstructive sleep apnea. U.S. Food and Drug Administration, Dec 20, 2024.
- Zepbound prescribing information (217806s050). U.S. Food and Drug Administration, Apr 2026.
- FDA's concerns with unapproved GLP-1 drugs used for weight loss. U.S. Food and Drug Administration, Oct 1, 2026.
- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). New England Journal of Medicine (PubMed), Jun 4, 2022.
This page is general information, not medical advice. Talk with a licensed clinician about your own care.