Ketamine therapy cost: Spravato, IV clinics and at-home programs

What ketamine therapy costs, by type

Ketamine therapy cash prices, checked Oct 25 2026

Type	Price	What is included	Checked	Source
Spravato (esketamine nasal spray), cash	$882.23 to $1,319.41 per session	The drug only, by kit size; the REMS-enrolled clinic bills the 2-hour observation visit separately	Oct 25 2026	[1]
Spravato with commercial insurance and the maker's savings program	As little as $10 per treatment for the medicine	Medicine cost only; does not cover observation; not for Medicare, Medicaid, TRICARE or VA	Oct 25 2026	[5]
IV ketamine infusion, Boulder Community Health	$651 per infusion	Infusion sold through MDsave vouchers; psychiatric visits may be billed to insurance	Oct 25 2026	[2]
At-home ketamine, Mindbloom, 6 sessions	$1,290 ($215 a session)	Medicine, two clinician consults, three guide sessions	Oct 25 2026	[3]
At-home ketamine, Mindbloom, 18 sessions	$2,970 ($165 a session)	More guide and clinician time	Oct 25 2026	[3]

These are per-session prices, and none of these treatments is a single visit. Ask any clinic how many sessions it plans in the first month and after, and get the total in writing. We do not give doses or session schedules on this page.

Spravato: the FDA-approved option

Spravato is esketamine nasal spray. Its label covers two uses in adults: treatment-resistant depression, alone or with an oral antidepressant, and depressive symptoms in major depressive disorder with acute suicidal thoughts or behavior, given with an oral antidepressant ^[6].

It is available only through a restricted program called a REMS. It is dispensed and given only in healthcare settings enrolled in the REMS, a clinician must watch you for at least 2 hours after each dose, and you must not drive or operate machinery until the next day after a restful sleep ^[6]. That observation time is why the clinic bills for more than the drug.

Spravato and insurance

• Commercial plans. Aetna, for example, covers Spravato for treatment-resistant depression when the patient has had an inadequate response to two antidepressants from at least two different classes, each for at least 8 weeks, plus an augmentation trial or psychotherapy. It must be prescribed by or with a psychiatrist and given under direct supervision with 2 hours of monitoring ^[8]. Other plans set their own rules, so ask yours about prior authorization.
• The maker's savings program. Spravato withMe lets people with commercial insurance pay as little as $10 per treatment for the medicine. It has an annual maximum, it does not cover the observation visit, and it is not open to people on Medicare, Medicaid, TRICARE, the Department of Defense or VA ^[5].
• Medicare. Medicare contractor CGS tells clinics to bill Spravato sessions under codes G2082 and G2083, which include the drug and 2 hours of observation, with a modifier showing REMS enrollment ^[9]. Ask the clinic what your Part B share will be.

IV ketamine clinics: off-label and mostly self-pay

FDA has approved ketamine only as an injection for general anesthesia. In its 2023 warning, FDA said plainly: "Ketamine is not FDA approved for the treatment of any psychiatric disorder" ^[4]. Clinics that give IV ketamine for depression are using it off-label.

That shapes the bill. Boulder Community Health charges $651 per infusion through self-pay vouchers and does not bill insurance for the infusion ^[2]. University of Utah Health says ketamine infusions are not covered by insurance and must be paid before the infusion ^[10]. Aetna's policy calls ketamine experimental, investigational or unproven for depression by every route it lists, including IV ^[11].

At-home ketamine through telehealth

Mindbloom, one telehealth company, offers ketamine tablets or injections for use at home, at the same price either way ^[3]. It listed $1,290 for 6 sessions, $2,220 for 12 and $2,970 for 18 for new clients, and said it does not accept insurance, though it gives a superbill you can send to your plan ^[3]. It says it is available in 38 states ^[14]. Read our Mindbloom review for its record, including a wrongful death lawsuit filed in October 2025 whose claims are allegations; we found no ruling as of Oct 25 2026 ^[15].

We earn commissions from some partners, which can affect where they appear on this page. It never changes a verdict. How we make money

At-home ketamine program we have reviewed (Clean)

1. MMindbloom

   Clean

   Good fit for: an at-home ketamine program with guide sessions

   Price$1,290 for 6 sessions to $2,970 for 18, or $165 to $215 a session (checked Oct 25 2026) ^[3]

   What you get

   Compounded ketamine tablets or injections taken at home, with guide sessions ^[3]

   FDA record

   No warning letter to the company found ^[13]; see FDA's 2023 ketamine alert ^[4]

   BBB

   A, not accredited ^[12]

   Note

   No insurance; superbill provided ^[3]

   Visit Mindbloomon the Mindbloom website

Safety warnings to know before any session

Spravato carries a boxed warning for sedation, dissociation, slowed breathing, abuse and misuse, and suicidal thoughts and behaviors in young people taking antidepressants ^[6]. Its label also says:

• Who should not use it. People with aneurysmal blood vessel disease or an arteriovenous malformation, a history of bleeding in the brain, or an allergy to esketamine or ketamine ^[6].
• Blood pressure. It can raise blood pressure significantly, so the clinic checks it after each dose ^[6].
• Thinking and driving. It briefly affects attention and performance; no driving until the next day after a restful sleep ^[6].
• Pregnancy. It may cause fetal harm and is not recommended during pregnancy ^[6].
• Common side effects. Dissociation, dizziness, nausea, sedation, vertigo, numbness, anxiety, lethargy, higher blood pressure, vomiting and feeling drunk ^[6].

FDA's 2023 warning lists the same kinds of risks for ketamine used outside these controls ^[4]. Report side effects from compounded ketamine to FDA's MedWatch program ^[4].

Hidden costs

• Observation and visit fees. Spravato's cash drug price does not include the clinic's 2-hour observation visit ^{[1] [5]}.
• Psychiatric visits. Aetna requires a psychiatrist to prescribe or consult for Spravato ^[8]. Boulder Community Health bills psychiatric consultations apart from the $651 infusion, possibly to insurance ^[2].
• A ride home. No driving after Spravato until the next day after sleep, so plan transport ^[6].
• Repeat sessions. Prices on this page are per session or per program; ask how many sessions are planned and what follow-up costs.

How to choose safely

1. Start with your own doctor or psychiatrist. A concierge or private doctor can help coordinate care if you pay cash.
2. If you have depression that has not responded to two antidepressants, ask whether Spravato is an option and whether your plan covers it ^[8].
3. For any clinic, ask who monitors you, for how long, and what happens if your blood pressure or breathing changes ^{[4] [6]}.
4. Be wary of programs that skip in-person monitoring. FDA says home use adds risk ^[4].

If a clinic also offers wellness drips such as NAD+ or B12, compare those on our wellness injections page. Some peptides, such as Selank, are marketed for anxiety without FDA approval. How we choose what to cover is on our editorial standards page.